Debes H. Christiansen, M.Sc.



Head of Department, Pathology


Email: debesc@hfs.fo
Phone: +298 556486

Affiliation:

Faroese Food and Veterinary Agency

Education:

B.Sc. in Economy and Computer Science at the Copenhagen Business School, Denmark (1990)
M.Sc. in Molecular Biology at the University of Copenhagen, Denmark (1998)
  

Areas of interest:


  • Molecular Diagnostics
  • PCR
  • Gene sequencing

Publications:


  • Pedersen-Bjergaard J, Andersen MK, Christiansen DH: Therapy-related acute myeloid leukemia and myelodysplasia after high-dose chemotherapy and autologous stem cell transplantation. Blood. 95:3273-3279, 2000.
  • Christiansen DH, Andersen MK, Pedersen-Bjergaard J: Mutations with loss of heterozygosity of p53 are common in t-MDS and t-AML after exposure to alkylating agents and significantly associated with ľ5 and 5q-, a complex karyotype and a poor prognosis. J. Clin. Oncol. 19:1405-1413, 2001.
  • Andersen MK, Christiansen DH, Pedersen-Bjergaard J: Duplication or amplification of chromosome band 11q23 including the MLLgene is a recurrent abnormality in therapy-related MDS and AML, is closely related to mutations of the p53 gene and to previous therapy with alkylating agents. Genes Chromosomes Cancer. 31:33-41, 2001.
  • Andersen MK, Christiansen DH, Pedersen-Bjergaard J: Therapy-related acute lymphoblastic leukaemia with MLL rearrangements following DNA topoisomerase II inhibitors, an increasing problem: report on two new cases and review of the literature since 1992. Br J Haematol. 114:539-43, 2001.
  • Christiansen DH, Pedersen-Bjergaard J: Internal tandem duplications of the FLT3 and MLL genes are mainly observed in atypical cases of therapy-related leukemia with a normal karyotype and are unrelated to type of previous therapy. Leukemia. 15:1848-1851, 2001.
  • Pedersen-Bjergaard J, Andersen MK, Christiansen DH, Nerlov C: Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia. Blood 99:1909-1912, 2002.
  • Pedersen-Bjergaard J, Christiansen DH, Andersen MK, Skovby F: Causality of myelodysplasia and acute myeloid leukemia and their genetic abnormalities. Leukemia. 16:2177-2184, 2002.
  • Christiansen DH, Andersen MK, Pedersen-Bjergaard J: Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia. Leukemia. 17:1813-1819, 2003.
  • Christiansen DH, Andersen MK, Pedersen-Bjergaard J. Mutations of AML1 are common in therapy-related myelodysplasia following therapy with alkylating agents and are significantly associated with deletion or loss of chromosome arm 7q and with subsequent leukemic transformation. Blood. 104:1474-1481, 2004.
  • Andersen MK, Christiansen DH, Pedersen-Bjergaard J. Centromeric breakage and highly rearranged chromosome derivatives associated with mutation of TP53 are common in therapy-related MDS and AML after therapy with alkylating agents. A M-FISH study. Genes Chromosomes Cancer 42:358-371, 2005.
  • Christiansen DH, Andersen MK, Desta F, Pedersen-Bjergaard J. Mutations of genes in the receptor tyrosine kinase (RTK)/RAS-BRAF signal transduction pathway in therapy-related myelodysplasia and acute myeloid leukemia. Leukemia. 19:2232-2240, 2005.
  • Andersen MK, Christiansen DH, Pedersen-Bjergaard J. Amplification or duplication of chromosome band 21q22 with multiple copies of the AML1 gene and mutations of the TP53 gene in therapy-related MDS and AML. Leukemia 2005;19:197-200
  • Desta F, Christiansen DH, Andersen MK, Pedersen-Bjergaard J. Activating mutations of JAK2V617F are uncommon in t-MDS and t-AML and are only observed in atypic cases. Leukemia. 20:547-548, 2006.
  • Pedersen-Bjergaard J, Christiansen DH, Desta F, Andersen MK. Alternative genetic pathways and cooperating genetic abnormalities in the pathogenesis of therapy-related myelodysplasia and acute myeloid leukemia. Leukemia. 20:1943-1949, 2006.
  • Pedersen-Bjergaard J Andersen MK, Andersen MT, Christiansen DH. Haematologica reports. 2:18-22, 2006
  • Andersen MK, Christiansen DH, Petersen-Bjergaard J. Haematologica reports. 20:34-37, 2006
  • Christiansen DH, Desta F, Andersen MK, Pedersen-Bjergaard J. mutations of the PTPN11 gene in therapy-related MDS and AML with rare balanced chromosome translocations. Genes Chromosomes Cancer. 46:517-521, 2007
  • Pedersen-Bjergaard J, Andersen MK, Andersen MT, Christiansen DH. Genetics of therapy-related myelodysplasia and acute myeloid leukemia. Leukemia. 22:240-248, 2008.
  • Andersen MT, Andersen MK, Christiansen DH, Pedersen-Bjergaard J. NPM1 mutations in therapy-related acute myeloid leukemiawith uncharacteristic features. Leukemia. 22:951-955, 2008.
  • Gislason H, Karstensen H, Christiansen DH, Hjelti K, Helleland S, BŠverfjord G. Rib and vertebral deformities in rainbow trout (Oncorhynchus mykiss) explained by a dominant-mutation mechanism. Aquaculture. 309:86-96, 2010
  • Christiansen DH, ěstergaard PS, Snow M, Dale OB, Falk K. A low-pathogenic variant of infectious salmon anemia virus (ISAV-HPR0) is highly prevalent and causes a non-clinical transient infection in farmed Atlantic salmon (Salmo salar L.) in the Faroe Islands. J. Gen. Virol. 92:909-918, 2011.
  • Markussen T, Sindre H, Jonassen CM, Tengs T, Kristoffersen AB, Ramsell J, Numanovic S, Hjortaas MJ, Christiansen DH, Bendik-Dale O, Falk K. Ultra-Depp Pyrosequencing of Partial Surface Protein Genes from Infectious Salmon Anaemia Virus (ISAV) Suggest Novel Mechanisms Involved in Transition to Virulence. PLoS ONE 8:e81571, 2013
  • Petersen MS, Bech S, Christiansen DH, Schmedes AV, Halling J. The role of vitamin D and vitamin D receptor polymorphism on Parkinsonĺs disease in the Faroe Islands. Neuroscience Letters. 561:74-79, 2014
  • McBeath A, Aamelfot M, Christiansen DH, Matejusova I, Markussen T, Kaldhusdal M, Bendik-Dale O, Weli S, Falk K. Immersion challenge with low and highly virulent infectious salmon anaemia virus (ISAV) reveals different pathogenesis in Atlantic salmon. (paper submitted)